Lead Toxicity in Pregnancy and Newborns: A Case Report
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Authors: Shantanu Rastogi a;
Irina Kats a; Malka Messner a; Sushma Nakra
a; Warren Seigel a
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Published
in: 
Journal of Children's
Health, Volume 1, Issue 3 July 2003 , pages 355 - 360
Journal of Children's
Health, Volume 1, Issue 3 July 2003 , pages 355 - 360
Abstract
In 1991, the Centers for Disease
Control and Prevention (CDC) recommended that blood lead levels of 10 µg/dl
or more in children be regarded as detrimental to health and that
intervention be initiated to reduce blood lead levels in such cases. Lead
crosses the placenta throughout pregnancy. Exposure of the fetus to lead
affects it and the pregnant state of the mother in a multitude of ways,
including an increased
risk of abortions and premature labor. We describe a case of high
lead levels in a woman with a history of recurrent abortions and her subsequent normal pregnancy
and delivery after reduction of the lead levels through education and dietary
interventions.
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Keywords:
lead toxicity;
fetus; pregnancy; abortions
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Congenital
Anomalies in Lead Poisoning.
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Accession Number
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00006250-197302000-00020.
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Author
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GILANI, SHAMSHAD H. PhD
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Institution
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From the Department of Anatomy, New
Jersey Medical School, Newark, New Jersey 07103
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Title
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Congenital Anomalies in Lead
Poisoning.[Article]
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Source
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Obstetrics & Gynecology.
41(2):265-269, February 1973.
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Abstract
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The effects of lead on chick embryos
were analyzed in the present study. Two-day-old embryos were given varying
doses of lead acetate (0.005-0.080 mg/egg) and were examined on day 8 of
incubation. The LD, was 0.030 nig/egg. The principal malformations observed were:
reduced body size, micromelia and twisted limbs, shortened and twisted neck,
shortened beak, microplithalmia, ruptured brain and everted viscera. The must
common developmental anomalies were retarded growth and neck abnormalities. A
positive dose-response relationship was observed. The rate at which
malformations develuped increased with increasing doses of lead. The
incidence of gross abnormalities among the controls was very low. The results
of this study reveal that lead is teratogenic to chick cmbryogenesis.
(C) 1973 The American College of Obstetricians and Gynecologists |
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